Paraquat induces redox imbalance and disrupts glutamate and energy metabolism in the hippocampus of prepubertal rats

Nathalia Ferrazzo Naspolini,Carla Elise Heinz Rieg,Vitoria Hayduck Cenci,Daiane Cattani,Ariane Zamoner

NeuroToxicology（2021）

Cited 9|Views2

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Abstract

•Paraquat leads to glutamate neurotoxicity.•Oxidative stress is involved in Paraquat-induced neurotoxicity.•NMDA receptor activation by Paraquat causes Ca2+ influx.•Paraquat neurotoxicity involves GSK-3β and NF-κB activation.

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Key words

Paraquat,Glutamate,Oxidative stress,Energy metabolism,Calcium,Glucose transport

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