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Genomic survey of SARS-CoV-2 vaccine breakthrough infections in healthcare workers from Kerala, India

J. Beena Philomina, Bani Jolly, Neethu John, Rahul C. Bhoyar, Nisha Majeed, Vigneshwar Senthivel, C. P. Fairoz, Mercy Rophina, Bindhu Vasudevan, Mohamed Imran, Prasanth Viswanathan, V. R. Arvinden, Anoop Joseph, Mohit Kumar Divakar, Priyanka R. Nair, Afra Shamnath, P. Jayesh Kumar, Abhinav Jain, P. Geetha, Anjali Bajaj, Samatha Mathew, Vishu Gupta, Srashti Jyoti Agrawal, Vinod Scaria, Sridhar Sivasubbu, Chandni Radhakrishnan

The Journal of infection（2021）

Cited 57|Views7
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Abstract
We describe genomic analysis of SARS-CoV-2 isolates from breakthrough infections in six healthcare workers following vaccination with AZD1222/Covishield. Four patients were infected by the variant of concern B.1.1.7 while other isolates possessed E484K and S477N mutations in spike protein associated with immune escape.
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