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Alternative Mechanism of Action of the DNP PtIV Prodrug: Intracellular Cisplatin Release and the Mitochondria-Mediated Apoptotic Pathway

Olga Krasnovskaya,Daniil Spector,Alexander Erofeev,Peter Gorelkin,Roman Akasov,Dmitry Skvortsov,Alexander Trigub,Ksenia Vlasova,Alevtina Semkina,Nikolay Zyk,Elena Beloglazkina,Alexander Majouga

Dalton Transactions（2021）

Cited 6|Views54
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Abstract
In a recent research paper Dr. Suxing Jin et al. reported two multispecific PtIV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.
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Dioxygen Activation
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