Alternative Mechanism of Action of the DNP PtIV Prodrug: Intracellular Cisplatin Release and the Mitochondria-Mediated Apoptotic Pathway
Dalton Transactions(2021)
Abstract
In a recent research paper Dr. Suxing Jin et al. reported two multispecific PtIV complexes DNP and NP with non-steroidal anti-inflammatory drug naproxen (NPX) as the axial ligand(s). Herein, we clarify the mechanism of action of DNP, its therapeutic target and intracellular redox-status.
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Key words
Dioxygen Activation
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