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[11C]K-2 image with positron emission tomography represents cell surface AMPA receptors

Tetsu Arisawa,Tomoyuki Miyazaki,Wataru Ota,Akane Sano,Kumiko Suyama,Yuuki Takada,Takuya Takahashi

Neuroscience Research（2021）

Cited 5|Views7
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Abstract
•K-2OH, a major metabolite of K-2, does not penetrate cell membrane.•K-2OH slowly passed through the blood brain barrier (BBB) with paracellular transport.•Efflux of K-2OH from the brain is not a transporter-dependent.•The amount of cell surface AMPAR positively correlates with that of total AMPAR.
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Key words
AMPA receptor,Positron emission tomography,Blood brain barrier,Transporter,Cell membrane presentation,P2 fraction
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