Abstract 435: Mouse models of human cancer

Abstract Mouse models play a crucial role in understanding the genetic and genomic basis of cancer and for the development of novel cancer therapies. Because data and information about these models are distributed and heterogeneous, gaining an appreciation for which models have been developed and what their characteristics are presents a major challenge for cancer researchers. The Mouse Models of Human Cancer Database (MMHCdb; http://tumor.informatics.jax.org) solves this challenge by providing a comprehensive, expertly curated on-line information resource about genetically engineered (GEMMs) and inbred mouse models of human cancer. In partnership with the European Bioinformatics Institute (EMBL/EBI), MMHCdb has also developed and implemented PDX Finder, a global catalog of Patient Derived Xenograft models (https://www.pdxfinder.org). Both MMHCdb and PDX Finder employ metadata standards to simplify the process of searching for relevant mouse models by diverse criteria including cancer type, type of strain, and genetic alteration. MMHCdb contains more than100,000 records on tumor frequency data for over 7,600 different mouse strains. These data are linked to over 4,700 references, 2,900 pathology reports, and 6,900 images. PDX Finder provides researchers with one stop access to information about more than 2,800 PDX models in repositories from around the world. MMHCdb and PDX Finder are supported, in part, by NIH/NCI CA089713. MMHCdb was formerly called the Mouse Tumor Biology database (MTB). Citation Format: Carol J. Bult, Debra M. Krupke, Steven B. Neuhauser, Joel E. Richardson, John P. Sundberg. Mouse models of human cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 435.