Small Intestinalization Of Colon Using Ileum Organoids

Given themismatch in size and morphology of intestinal organoids with native intestine, their application in intestinal segment regeneration has yet to be achieved. By engrafting ileal organoids in epitheliumremoved colon, Sugimoto et al. recently constructed transplantable colonic segments with functional ileal epithelium and a subepithelial lymphovascular system, providing hope for the treatment of short bowel syndrome.