7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts

Ok-Joo Sul,Guoen Li,Ji-Eun Kim,Eun-Sook Kim,Hye-Seon Choi

The Journal of Nutritional Biochemistry（2021）

引用 13|浏览2

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摘要

•Atherogenic diet increased 7-ketocholesterol (7-KC) in bone.•Bone resorption was associated with cholesterol and ROS in humans and mice.•7-KC increased the number and activity of OCs by enhancing autophagy.•7-KC enhanced autophagy via the ROS-TFEB signaling pathway.

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关键词

7-ketocholesterol,Osteoclast,autophagy,Reactive oxygen species,Transcription factor EB

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