Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ

Aisha Alnami,Raymond S Norton, Helena Perez Pena,Shozeb Haider,Frank Kozielski

Journal of Molecular Biology（2021）

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摘要

•Mycobacterium tuberculosis FtsZ is a potential antibacterial target.•Xray structures of Mtb FtsZ in complex with a coumarin are presented.•We identify two novel inhibitor-binding cryptic pockets.•Cryptic pocket formation is controlled by the dynamics of H7 helix.

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关键词

Mycobacterium tuberculosis,FtsZ,cryptic pockets,coumarin,antibacterial

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