Recombinant FimH, a fimbrial tip adhesin of Vibrio parahaemolyticus, elicits mixed T helper cell response and confers protection against Vibrio parahaemolyticus challenge in murine model

•Recombinant FimH of V. parahaemolyticus (rVpFimH) was purified to near homogeneity.•The rVpFimH generated T-cell memory and mixed immune response in BALB/c mice.•Agglutination positive anti-rVpFimH antiserum cross-reacted with VpFimH.•Immunization with rVpFimH conferred 100 % protection against bacterial challenge.