Tripartite synaptomics: Cell-surface proximity labeling in vivo
Neuroscience Research(2021)
Abstract
•A proximity-based labeling TurboID-surface enables to map and identify the cell surface proteins from brain tissue.•Split-TurboID enables the mapping and molecular profiling at specific cell-type interfaces in vivo.•Astrocytes control excitatory and inhibitory synapse formation and function in vivo.
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Key words
Split-TurboID,BioID,Astrocyte,Synapse,Neuron,Tripartite synapse,Synaptomics
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