Design And Synthesis Of Gene-Directed Caged Cyclic Nucleotides Exhibiting Cell Type Selectivity

Akinobu Z Suzuki, Taichi Sakano,Hirona Sasaki,Rei Watahiki,Masaki Sone,Kazuki Horikawa,Toshiaki Furuta

CHEMICAL COMMUNICATIONS（2021）

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摘要

We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve as a strategy for adding targeting abilities to photocaged compounds.

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关键词

cyclic nucleotides,cell type selectivity,cell type,synthesis,gene-directed

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