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Zidovudine in synergistic combination with fosfomycin: an in vitro and in vivo evaluation against multidrug-resistant Enterobacterales

Roberta Maria Antonello,Stefano Di Bella,Jonathan Betts,Roberto La Ragione,Raffaela Bressan,Luigi Principe,Stefano Morabito,Federica Gigliucci,Rosangela Tozzoli,Marina Busetti,Anna Knezevich,Linda Furlanis, Francesco Fontana,Francesco Luzzaro,Roberto Luzzati,Cristina Lagatolla

International Journal of Antimicrobial Agents（2021）

Cited 13|Views14
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Abstract
•Fosfomycin (FOF) is an antibiotic option against multidrug-resistant (MDR) Enterobacterales.•Zidovudine (ZDV) has unexploited antibacterial properties.•Study of ZDV in combination with FOF against MDR Enterobacterales.•In vitro, ZDV restored FOF susceptibility in ~90% of resistant strains.•In vivo, G. mellonella survival was higher (20–50%) with FOF + ZDV combination.
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Key words
Zidovudine,Fosfomycin,MDR Enterobacterales,STEC,Synergistic effect,Galleria mellonella
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