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Interleukin-17 Induces Pyroptosis in Osteoblasts Through the NLRP3 Inflammasome Pathway in Vitro

Lihong Lei,Jianwei Sun,Jiayin Han,Xiaojian Jiang,Zhongxiu Wang,Lili Chen

INTERNATIONAL IMMUNOPHARMACOLOGY（2021）

Cited 32|Views14
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Abstract
•IL-17 induced pyroptosis of osteoblasts in vitro.•Il-17 not only promoted the expression of IL-1β and RANKL, but also increased their secretion.•Inhibition of NLRP3 could attenuate pyroptosis in osteoblasts and decrease the release of related cytokines.
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Key words
IL-17,Primary osteoblasts,Pyroptosis,NLRP3,Bone metabolism
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