Sofosbuvir Resistance-associated Substitutions in the Palm Domain of HCV-NS5B RNA Dependent RNA Polymerase; Study of two Sofosbuvir non-responders.

Sana Ullah,Muhammad Ali,Asmat Shaheen,Fatima Zia,Lubna Rahman,Sidra Rahman,Hammad Ali,Misbahud Din,Abdul Waris,Zabta Khan Shinwari

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases（2021）

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Abstract

We have noticed that the current sequences are relatively emerging and could have been originated from aforementioned sequence recently. Based on the current results, we suggests that these substitutions could be associated with structural or functional impairment of protein and could also be may be considered as resistance associated substitutions (RAS) to Sofosbuvir drug.

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Key words

Hepatitis C virus,NS5B protein,amino acid substitution,phylogenetics,protein modelling

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