Sofosbuvir Resistance-associated Substitutions in the Palm Domain of HCV-NS5B RNA Dependent RNA Polymerase; Study of two Sofosbuvir non-responders.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases(2021)

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Abstract
We have noticed that the current sequences are relatively emerging and could have been originated from aforementioned sequence recently. Based on the current results, we suggests that these substitutions could be associated with structural or functional impairment of protein and could also be may be considered as resistance associated substitutions (RAS) to Sofosbuvir drug.
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Key words
Hepatitis C virus,NS5B protein,amino acid substitution,phylogenetics,protein modelling
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