Genomic Analysis of the Predominant Strains and Antimicrobial Resistance Determinants Within 1479 Neisseria gonorrhoeae Isolates From the US Gonococcal Isolate Surveillance Project in 2018
SEXUALLY TRANSMITTED DISEASES(2021)
摘要
Background: The prevalence of Neisseria gonorrhoeae (GC) isolates with elevated minimum inhibitory concentrations to various antibiotics continues to rise in the United States and globally. Genomic analysis provides a powerful tool for surveillance of circulating strains, antimicrobial resistance determinants, and understanding of transmission through a population. Methods: Neisseria gonorrhoeae isolates collected from the US Gonococcal Isolate Surveillance Project in 2018 (n = 1479) were sequenced and characterized. Whole-genome sequencingwas used to identify sequence types, antimicrobial resistance profiles, and phylogenetic relationships across demographic and geographic populations. Results: Genetic characterization identified that (1) 80% of the GC isolates were represented in 33multilocus sequence types, (2) isolates clustered in 23major phylogenetic clusters with select phenotypic and demographic prevalence, and (3) common antimicrobial resistance determinants associated with low-level or high-level decreased susceptibility or resistance to relevant antibiotics. Conclusions: Characterization of this 2018 Gonococcal Isolate Surveillance Project genomic data set, which is the largest US whole-genome sequence data set to date, sets the basis for future prospective studies, and establishes a genomic baseline of GC populations for local and national monitoring.
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关键词
neisseria gonorrhoeae isolates,antimicrobial resistance,antimicrobial resistance determinants,predominant strains
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