Hyaluronic acid-decorated carborane-TAT conjugation nanomicelles: A potential boron agent with enhanced selectivity of tumor cellular uptake

Colloids and Surfaces B: Biointerfaces(2021)

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摘要
•Hyaluronic acid-decorated carborane-TAT conjugation nanomicelles was fabricated by layer-by-layer self-assembly approach.•The core-shell structure Carborane-TAT@HA nanomicelle showed enhanced selectivity of tumor cellular uptake.•Carborane-TAT@HA nanomicelle has great potential to be used as a boron drug for BNCT.
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关键词
Boron neutron capture therapy,o-Carborane,Cell-penetrating peptide,Hyaluronic acid,Enhanced tumor-selected cellular uptake
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