Switching the Proteolytic System from the Ubiquitin–Proteasome System to Autophagy in the Spinal Cord of an Amyotrophic Lateral Sclerosis Mouse Model

Koh Tadokoro,Toru Yamashita,Jingwei Shang,Yasuyuki Ohta,Emi Nomura,Ryuta Morihara,Yoshio Omote,Mami Takemoto,Koji Abe

Neuroscience（2021）

引用 4|浏览7

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摘要

•Switch from UPS to autophagy occurred at end stage of ALS.•Not only in motor neurons but also in astroglia were involved this switch.•Autophagic flux was impaired in ALS.

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关键词

Amyotrophic lateral sclerosis,Autophagy,Proteostasis

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