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Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae

Lance R. Fredericks,Mark D. Lee, Hannah R. Eckert,Shunji Li,Mason A. Shipley,Cooper R. Roslund,Dina A. Boikov,Emily A. Kizer,Jack D. Sobel,Paul A. Rowley

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY（2021）

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Abstract
Compared to other species of Candida yeasts, the growth of Candida glabrata is inhibited by many different strains of Saccharomyces killer yeasts. The ionophoric K1 and K2 killer toxins are broadly inhibitory to all clinical isolates of C. glabrata from patients with recurrent vulvovaginal candidiasis, despite high levels of resistance to clinically relevant antifungal therapeutics.
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Key words
Candida glabrata,Saccharomyces,antifungals,azole,candidiasis,killer toxins,polyene,vulvovaginal
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