Growth hormone replacement may influence the biological action of thyroid hormone on liver and bone tissue

Nigel Glynn,David J Halsall,Gerard Boran,Paul Cook,John H McDermott,Diarmuid Smith,William Tormey,Christopher J Thompson,Donal O'Gorman,Malachi J McKenna,Amar Agha

Growth Hormone & IGF Research（2021）

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摘要

•Growth hormone modulates peripheral action of thyroid hormone in several tissues including liver and bone.•Replacement of growth hormone may improve the biological action of thyroid hormone in bone.•Alteration of thyroid hormone metabolism by growth hormone therapy may induce a more hypothyroid hepatic phenotype

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关键词

Growth hormone deficiency,Thyroid hormone action,Central hypothyroidism,Hepatic biomarkers,Bone biomarkers

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