Total synthesis of (-)-brazilane via a lipase-catalyzed desymmetrisation reaction
NATURAL PRODUCT RESEARCH(2022)
Abstract
Herein, we described the asymmetric total synthesis of (-)-brazilane, an optically active natural product. The key steps of this synthetic approach are a lipase-catalyzed desymmetrisation reaction of a prochiral diol using vinyl acetate to prepare a chiral primary alcohol and a trifluoroacetic acid-catalyzed one pot intramolecular tandem Prins/Friedel-Crafts reaction used to construct the cis-fused chromane and indane framework. [GRAPHICS] .
MoreTranslated text
Key words
Total synthesis, (-)-brazilane, natural product, lipase-catalyzed desymmetrisation, tandem Prins/Friedel-Crafts reaction
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined