Renaissance of 4-(5-nitrofuran-2-yl)-5-arylamino substituted pyrimidines: microwave-assisted synthesis and antitubercular activity
Mendeleev Communications(2021)
摘要
The Buchwald-Hartwig cross-coupling of 5-bromo-4(furan-2-yl)pyrimidine with various anilines afforded the corresponding new 5-(arylamino)pyrimidines, the reaction being accelerated by microwave irradiation. Most of the obtained compounds proved to possess a high bacteriostatic in vitro effect against Mycobacterium tuberculosis H(37)Rv, Neisseria gonorrhoeae, and Staphylococcus aureus including Methicillin-resistant strain, which is stronger than that of the commercial drug Spectinomycin.
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关键词
pyrimidines,nitrofurans,anti-mycobacterial activity,Buchwald-Hartwig amination,cross-coupling reactions
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