The Value Of (68)Gallium-Dotatate Pet/Ct In Sinonasal Neuroendocrine Tumor Management: A Case Series

Background (68)Gallium-DOTATATE (Ga-68-DOTATATE) is a somatostatin analog used as a PET tracer to successfully identify neuroendocrine tumors (NETs). Due to the rarity of sinonasal NETs, there are few recommendations for Ga-68-DOTATATE imaging in these patients.Methods We discussed the impact of Ga-68-DOTATATE imaging on the management of six sinonasal NET cases and reviewed existing literature.Results Ga-68-DOTATATE PET/CT revealed an unknown primary in one case and identified metastatic disease in a primary sinonasal small cell neuroendocrine carcinoma (SNEC) patient missed on conventional imaging. In two esthesioneuroblastoma (ENB) patients, Ga-68-DOTATATE detected abnormal radiotracer uptake not present on 18F-FDG PET/CT and identified a patient for treatment with Lu-177-DOTATATE.Conclusions This is the one of the first few reports, and the largest series to our knowledge, demonstrating the utility of Ga-68-DOTATATE imaging for primary sinonasal SNEC and ENB. Further study is required to determine its role in sinonasal NET management.