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Route Design to Manufacture: Synthesis of the Heterocyclic Fragment of AZD5718 Using a Non-cryogenic Lithiation-Alkoxycarbonylation Reaction

Matthew Burns,Dave Perkins,Lai C. Chan,Michael J. Pilling,Anna Jawor-Baczynska,Alexander K. Mullen,Alan Steven, Chris Wimsey,Ahmed Elmekawy,Alex Lamacraft,Benjamin C. Dobson,Angus E. McMillan,David R. J. Hose,Phillip A. Inglesby,Steven A. Raw,Martin F. Jones

Organic Process Research & Development（2021）

引用 3|浏览17
关键词
route design,pyrazole,lithiation-alkoxycarbonylation,reduction-cyclization
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