Enantioselective Total Synthesis Of Sesquiterpenoid Phellilane L And Its Diastereomer

The enantioselective synthesis of phellilane L has been accomplished in six-steps with overall 36% yield. The quinidine-based organocatalytic cyclopropanation of vinyl-ketone with 2-bromo-N,O-dimethylacetamide for the stereoselective construction of substituted cyclopropanes and substrate-controlled methyl Grignard addition to theWeinreb amide are the key steps responsible for the stereoselective synthesis of natural products. (C) 2021 Elsevier Ltd. All rights reserved.