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Pharmacodynamic Effect Of Aro-Ang3, An Investigational Rna Interference Targeting Hepatic Angiopoietin-Like Protein 3, In Patients With Hypercholesterolemia

Gerald F. Watts,Christian Schwabe,Russell Scott,Patrick Gladding,David Sullivan,John Baker, Peter Clifton,James Hamilton,Bruce Given,Javier San Martin,Stacey Melquist,Ting Chang,Natasa Rajicic,Ira J. Goldberg,Daniel Gaudet,Joshua W. Knowles,Robert A. Hegele, Christie M. Ballantyne

Circulation（2020）

Cited 29|Views18
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Abstract
Background: Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride (TG) and lipoprotein (LP) metabolism by inhibiting liver and endothelial LP lipases and reduces plasma LDL-C. In Phase 1 Stu...
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Key words
rna,pharmacodynamic effect,aro-ang,angiopoietin-like
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