Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes
ACS catalysis（2021）
关键词
biocatalysis,class I lyase-like enzyme,phenylalanine ammonia-lyase,phenylalanine 2,3-aminomutase,crystal structure,mechanism-based inhibition,substrate-binding dynamics,tunnel engineering
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