Synthesis of 4,4′-substituted 2,2′-[ethane-1,2-diylbis(selanediyl)]bis(1 H -imidazol-5(4 H )-ones)

A. V. Finko, A. I. Sokolov, L. A. Vasilyeva,D. A. Skvortsov, A. S. H. Al-Khazraji,E. N. Ofitserov,N. V. Zyk, A. G. Majouga, E. K. Beloglazkina

Russian Chemical Bulletin（2021）

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摘要

Synthesis of new bis(seleno-imidazolone) derivatives bearing the alkyl and aryl moieties at the N(1) atom of the five-membered ring was developed. Cytotoxicity of the synthesized compounds against A549, VA-13, MCF-7, and HEK293T cell lines was evaluated.

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关键词

imidazolone,2-selenohydantoine,bis(seleno) derivatives,organoselenium compounds,alkylation,cytotoxicity,MTT test,in vitro

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