Palladium-Catalyzed One-Pot Synthesis Of 2-Substituted Quinazolin-4(3h)-Ones From O-Nitrobenzamide And Alcohols

Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily available o-nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including alcohol oxidation, nitro reduction, condensation, and dehydrogenation occurs without any added reducing or oxidizing agent.