Cholestatic Liver Injury In Covid-19 Is A Rare And Distinct Entity And Is Associated With Increased Mortality
JOURNAL OF INTERNAL MEDICINE(2021)
摘要
Current evidence indicates that the development of acute hepatocellular liver injury during coronavirus disease 2019 (COVID-19) is associated with more severe COVID-19 disease.[1] Since SARS-CoV2 is able to enter the liver via the ACE2 receptor proteins located on the epithelium of bile ducts, direct viral cholangiocyte injury is theoretically a possible pathogenic mechanism of the virus resulting in cholestatic liver injury.[2] Supporting this idea: a recent meta-analysis that reported serum alkaline phosphatase (ALP) elevations occurs in up to 13.7% of patients[3], a case series describing the clinical/histologic features of three patients with COVID-19 cholangiopathy[4], and a recent study reporting higher fatality rates in COVID-19 patients with cholestasis.[5].
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关键词
COVID-19, SARS-CoV2, cholestasis, alkaline phosphatase, mortality
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