Targeted Deep Next Generation Sequencing Identifies Potential Somatic And Germline Variants For Predisposition To Familial Burkitt Lymphoma

Motohito Okabe,Takanobu Morishita,Takahiko Yasuda,Hirotoshi Sakaguchi,Masashi Sanada,Keisuke Kataoka,Seishi Ogawa,Yuichi Shiraishi,Tomoe Ichiki,Yuka Kawaguchi,Marie Ohbiki,Rena Matsumoto,Masahide Osaki,Tatsunori Goto,Yukiyasu Ozawa,Koichi Miyamura

EUROPEAN JOURNAL OF HAEMATOLOGY（2021）

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摘要

The genetic landscape of Burkitt lymphoma (BL) has been elucidated over decade, however, few reports have described genetic basis for its pathogenesis in familial BL [1-5]. Here, we performed targeted deep next generation sequencing of Japanese dizygotic twins who were diagnosed with BL (Supplemental Figure 1a).

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