Cytokine Storm Induced By A Pd1 Inhibitor In A Renal Transplant Patient
AMERICAN JOURNAL OF TRANSPLANTATION(2021)
摘要
Transplant patients are excluded from immunotherapy trials and therefore require more attention if such a treatment is deemed necessary. There should be an established procedure for managing immune-related adverse events (irAEs) secondary to PD-1/PD-L1 blockade because of the high rejection rate (371 to 80% 2,3 ) and the subsequent mortality, especially in non-kidney recipients3 ,4 . CTLA4 agonist has been identified as a nivolumab antidote for fulminant myocarditis in naive patients but it may be insufficient in primed patients with a much stronger alloimmune response.
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关键词
clinical research, practice, cytokines, cytokine receptors, immunosuppression, immune modulation, kidney transplantation, nephrology, macrophage, monocyte biology, activation
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