Enantioseparation and modelling study of six proton pump inhibitors on a novel 3, 5-dichloro-phenylcarbamated β-cyclodextrin chemically bonded chiral stationary phase by high performance liquid chromatography
Microchemical Journal(2021)
Abstract
•A novel β-CD derivative chemically bonded CSP, MDCPC, was successfully prepared and characterized.•MDCPC showed the satisfactory enantioselectivity for PPIs under various HPLC conditions.•Chiral recognition mechanisms were illustrated firstly by molecular docking technique from the molecular level.•Hydrogen bonding, hydrophobic interaction and inclusion complexation played an important role in enantioseparation.
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Key words
β-Cyclodextrin derivative,Chiral stationary phase,MDCPC,High performance liquid chromatography,Enantioseparation,Molecular docking
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