Synthesis and Biodistribution of ~(131)I-BIB

The synthesis and biodistribution of 131I-1-iodo-2,5-bis(4\u0027-amino)styrylbenzene(131I-BIB) were reported.The chemical structure of the labeling precursor 1-tributylstannyl-2,5-bis(4\u0027-amino)styrylbenzene and all its intermediates were verified by IR,1H NMR and MS respectively.The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide.Labeling yield was more than 60% and radiochemical purity was more than 90% determined by thin layer chromatography(TLC).The in vivo biodistribution of 131I-BIB in ICR mice showed that the value of brain uptake was the highest in 30 min.