The Frequency And Impact Of Ikzf1 Deletions On Minimal Residual Disease In Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia Patients Treated In Russian Acute Lymphoblastic Leukemia Study

Background: The incidence of IKZF1 gene deletions is approximately 20 % in adult patients with BCR-ABL1- negative B-cell acute lymphoblastic leukemia (BCR-ABL1-neg ALL). These mutations are associated with poor prognosis. Minimal residual disease (MRD) positivity at postinduction time increases incidence of relapse. IKZF1 gene deletions are frequently associated with MRD measured at the end of induction using flow cytometric techniques.