P35.27 Next Generation Sequencing Reveals the Genetic Landscape of JAK Family in Chinese Lung Cancer Patients

Gain-of-function mutations of JAK genes are the main molecular pathogenesis of hematologic malignancies, such as myeloproliferative neoplasm (MPN), polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF) and adult acute lymphocytic leukemia (ALL). Some studies have shown that the constitutive activation of JAK pathway is related to EGFR-TKI resistance in lung cancer patients, but the genomic mutational status of JAK gene family in lung cancer remains unclear.