Two Zn(II) Coordination Polymers: Luminescent Sensing Property and Treatment Activity on Uterine Leiomyomas by Reducing TGF-β Releasing and mmp-3 and mmp-7 Expression

Under solvothermal conditions, two new Zn(II)-based coordination polymers, namely {[Zn(tptc) 0.5 (2,2′-bpy)]·dioxane} n ( 1 , H 4 tptc = p-terphenyl-2,2″,5″,5‴-tetracarboxylate acid, 2,2′-bpy = 2,2′-bipyridine) and [Zn(tptc) 0.5 (bib)] n ( 2 , bib = 1,3-bis((imidazol-1-yl) benzene), have been synthesized using the mixed-ligand approach. Furthermore, the luminescence studies show that complex 2 can test acetylacetone selectively and sensitively, and the detection limit is 1.72 ppm. In addition, we evaluated the compounds therapeutic effect against uterine leiomyomas. The uterine leiomyomas rats model was established, the compound 1 and compound 2 was used for treatment. The detection of the transforming growth factor-β (TGF-β) releasing from endometrial stromal cells into plasma was detected with an enzyme linked immunosorbent assay (ELISA) detection kit. Then, the mmp-3 and mmp-7 relative expression levels in the uterine smooth muscle cells after compound treatment were measured by the reverse transcription-polymerase chain reaction (RT-PCR).