Inhibitory Effects of Bryophyllum pinnatum Leaf Extract on Inflammatory Biomarkers

Bryophyllum pinnatum Lam. (Crassulaceae) called ‘Oda-opue’ in Igbo and ‘Abamoda’ in Yoruba are widely used as food and as medicines in traditional medical practice. They are found widely in tropical Africa, America, India and China. This study investigated the inhibitory effect of the hydro-ethanol leaf extract on inflammatory biomarkers. The Cotton Pellet Induced Granuloma method was used in the study. The plant extract significantly inhibited the inflammatory biomarkers, cyclooxygenases 1 and 2, interleukins 1β and 6, and prostaglandin E2, in a dose dependent manner indicating a reduction of inflammation in the rats. The study showed that B. pinnatum leaf extract possess a rich content of bioactive compounds which could be synthesized to produce new plant-based product to fight inflammatory disorders with fewer side effects.