Two-photon polymerization nanofabrication of ultracompact light scattering spectroscopic probe for detection of pre-cancer in pancreatic cyst

•Pancreatic cancer has one of the lowest survival rates of all major cancers.•Pancreatic cystic lesions account for one in three pancreatic surgeries.•The low accuracy of the existing methods for diagnosis of pancreatic cyst malignancy highlights the crucial need for a more accurate diagnostic tool.•We present the design and two-photon polymerization based fabrication of refractive and reflective non-contact probes capable of rapid surveillance of the entire internal cyst surface.•These probes can be used clinically to perform rapid “optical biopsy”, ultimately eliminating unnecessary pancreatic surgeries on benign cysts and dangerous delays in surgical removal of malignant cysts, improving patient prognosis and quality of life.