Practical Synthesis of (3aR, 9bR)-8-Fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole: An Advanced Intermediate to Access the RORγt Inverse Agonist BMT-362265

Ananta Karmakar,Roshan Y. Nimje,Arundutt Silamkoti,Manivel Pitchai,Mushkin Basha,Christuraj Singarayer,Duraisamy Ramasamy,G. T. Venkatesh Babu,Ramesh Samikannu,Srinath Subramaniam,Prakash Anjanappa,Muthalagu Vetrichelvan,Hemantha Kumar,Amol G. Dikundwar,Anuradha Gupta,Arun Kumar Gupta,Richard Rampulla,T. G. Murali Dhar,Arvind Mathur

Organic Process Research & Development（2021）

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摘要

A practical and scalable route to (3aR, 9bR)-8-fluoro-7-(perfluoropropan-2-yl)-9b-(phenylsulfonyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole 10, an advanced intermediate en route to the synthesis o...

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关键词

tetralone,RORγt,immunology,heptafluoroisopropyl,vinylsulfone,BMT-362265

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