Expression of ID2 and Cyclooxygenase 2 Genes in Endometrial Tissues and Their Clinical Significance in the Pathogenesis of Endometrial Polyps

To investigate the expression of Deoxyribonucleic acid binding inhibitor 2 and Cyclooxygenase 2 genes in endometrial polyps patient's endometrial tissues and analyze their clinical significance is the main objective. 38 patients with endometrial polyps who were treated at the minimally invasive gynecologic and reproductive surgery department of our hospital from October 2020 to December 2020 were selected as the test group, and their polyps and the endometrial tissue around the polyps were taken. 36 cases of women who had undergone intrauterine device placement surgery at the same time were scraped from the endometrium before intrauterine device placement. The messenger ribonucleic acid expression and protein levels of deoxyribonucleic acid binding inhibitor 2 and cyclooxygenase 2 in endometrial tissues were detected by quantitative reverse transcription polymerase chain reaction and western blot. In addition, enzyme-linked immunosorbent assay was used to detect the levels of vascular endothelial growth factor, tumor necrosis factor-alpha, interleukin 1 beta and cancer antigen 125 and to analyze their relationship with the expression of Deoxyribonucleic acid binding inhibitor 2 and cyclooxygenase 2 in endometrial tissues of endometrial polyp's patients. The results showed that the expression of Deoxyribonucleic acid binding inhibitor 2 and cyclooxygenase 2 messenger ribonucleic acid and protein levels in endometrial tissues were significantly higher in the experimental group compared with the control group, and the difference was statistically significant. Deoxyribonucleic acid binding inhibitor 2 was positively correlated with vascular endothelial growth factor, tumor necrosis factor alpha, interleukin 1 beta and cancer antigen 125 (p<0.05), while cyclooxygenase 2 was positively correlated with interleukin 1 beta and cancer antigen 125 in the endometrial tissues of patients in the test group. The sensitivity of Deoxyribonucleic acid binding inhibitor 2 was 87.32 %, specificity was 64.88 % and cut-off value was 1.68; the sensitivity of cyclooxygenase 2 was 93.15 %, specificity was 84.33 % and cut-off value was 2.03. Deoxyribonucleic acid binding inhibitor 2 and cyclooxygenase 2 in endometrial tissues has a high predictive value for the clinical diagnosis of endometrial polyps. Expression is closely related to the development of endometrial polyps, and both may be candidate specific target genes for endometrial polyps, and both may be used as markers for the clinical diagnosis of endometrial polyps.