Synthesis and Characterization of Abacavir Acetic Acid Salt Polymorphic Transition from Abacavir Free Base by Using Process Analytical Tools (PAT)
Biochemical and Biophysical Research Communications(2020)
Abstract
Abacavir (ABC) is a guanosine analogue used to prevent and treat HIV/AIDS. It is a neucleoside reverse transcriptase inhibitor that inhibits viral replication and it is marketed as hemisulphate salt and with combination of lamivudin/zidovudin. Nevertheless, Abacavir succinic acid, malonic acid, sulfuric acid and HCl salts are mentioned in the literature. The novel acetic acid salt from Abacavir is mentioned here. In this study, we used Focused Beam Reluctant Measurement (FBRM) and Particle Vision Microscope (PVM) PAT tools to track the polymorphic transition from Abacavir free base to acetic acid salt, which is characterized by DSC, PXRD, FTIR, and 1HNMR to confirm the structure.
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Key words
PROCESS ANALYTICAL TOOLS,ABACAVIR,POLYMORPH,ACETIC ACID SALT
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