CNS relapse of childhood ALL: More than meets the eye

Relapse of childhood leukemia has protean manifestations. Bone marrow/central nervous system (CNS) and testis are the typical locations of relapse in acute lymphoblastic leukemia (ALL). Infrequently, the disease may relapse at atypical sites with unusual clinical features. In this communication, we present two cases of CNS relapse of ALL, who presented with unique clinical characteristics, the relapse of leukemia masquerading acute demyelinating polyradiculopathy in one patient and with flaccid quadriplegia in the second case.