Spectral, In Vitro Antiradical And Antimicrobial Assessment Of Copper Complexes Containing Tridentate Schiff Base Derived From Dihydroxybenzene Functionality With Diaminoethylene Bridge

The reaction of copper salts with Schiff base ligand: [4-[(1E)-N-{2-[(Z)-(4-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol] derived from the condensation of ethylenediamine, 2-hydroxy-1-(4-hydroxyphenyl)ethenone and 4-methoxybenzaldehyde afforded copper complexes bearing chloride, bromide, thiocyanate, nitrate, and acetate. The complexes exhibited crystalline features and excellent thermal stability up to 450 degrees C. The powder X-ray diffraction pattern suggests a well-defined crystalline structure with average crystallite sizes of < 52 nm. The scavenging ability of 2,2-diphenyl-1-picrylhydrazyl and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid radicals by the synthesized compounds was studied for their antioxidant potential and screening for antimicrobial activity by p-iodonitrotetrazolium chloride colorimetric assay. The investigated assays suggest that the synthesized compounds are potent antiradical and antimicrobial agents.