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Richter'S Transformation As Leptomeningeal Infiltration In A Chronic Lymphocytic Leukemia Patient Receiving Venetoclax. Could Blood-Brain Barrier Be A Disease "Sanctuary" During Venetoclax Treatment?

Maria Dimou,Aikaterini Bitsani,Maria Roumelioti,Aglaia Dimitrakopoulou,Theodore Iliakis,Vasileios Pardalis,Ioannis Grafakos,Sotiria Kalyva,Athanasios Markopoulos,Marie‐Christine Kyrtsonis,Panayiotis Panayiotidis

CLINICAL CASE REPORTS（2021）

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Abstract
Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood-brain barrier and at what extend, especially in reduced doses given for drug-drug interactions.
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blood&#8208, brain barrier, chronic lymphocytic leukemia, leptomeningeal infiltration, Richter&apos, s transformation, venetoclax
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