Single-Cell Dna Targeted Sequencing (Scdna-Seq) To Test Therapeutic Vulnerabilities In Urothelial Cancer (Uc) Patient-Derived Organoids (Pdo).

Kyrillus Shohdy,Weisi Liu,Alicia Alonso,Jenny Xiang,M. Laura Martin,Olivier Elemento,Bishoy Morris Faltas

JOURNAL OF CLINICAL ONCOLOGY（2021）

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摘要

464Background: Genomic alterations in FGFR3, PIK3CA, and CDKN2A are common actionable targets in urothelial cancer (UC). We aimed to determine the efficacy of alpelisib, a PIK3CA inhibitor, and abe...

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关键词

urothelial cancer,organoids,single-cell,scdna-seq,patient-derived

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