Non-Thermal Intervention Of Lung Tumor By Core-Shell Magnetic Nanoparticles In A Magnetic Field

Featured ApplicationThe options for the treatment of K-Ras-driven lung tumors are currently limited. This study investigates the potential for non-thermal intervention against lung tumors using magnetic nanoparticles (MNPs) in a magnetic field. The MNPs for use in treating tumors were prepared by chemical methods. Simulations showed that the experimental platform can generate the desired magnetic field by avoiding any damaging rise in temperature and that the induced magnetic force can affect the cellular activities. Using MNPs in a magnetic field in this way can not only suppress the growth of tumor cells but also can strengthen the inhibitory effects of magnetic field stimulation on the lung tumors caused by the K-Ras mutations.K-Ras mutations result in normal cells dividing uncontrollably and becoming cancerous. The prognosis is currently poor for patients due to the lack of drugs that can effectively target these mutations. In this study, magnetic nanoparticles (MNPs) were prepared, characterized, and cooperated with a magnetic field to intervene in the growth of lung tumor cells. The rise in temperature of a stimulation coil was studied by numerical calculation. The non-thermal effects of MNPs under a magnetic force were analyzed. The cell experiments showed that the growth of A549 tumor cells slowed down. The result of a wound-healing assay also indicated that the migration of tumor cells was suppressed. Compared with magnetic stimulation without MNPs, MNPs enhanced the inhibitory effects of a magnetic field. This study suggests a new way to treat K-Ras driven lung tumors using non-thermal effects of MNPs without the side effects caused by thermal effects.