ctDNA pathogenic variants (PVs) in homologous recombination repair (HRR) genes in patients with metastatic CRPC.

Ellen Jaeger,Elisa Marie Ledet,Marcus W. Moses,Charlotte Manogue,Brian E. Lewis,Jodi Lyn Layton,Pedro C. Barata,Oliver A. Sartor

JOURNAL OF CLINICAL ONCOLOGY（2021）

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摘要

138Background: HRR PVs can serve as predictive biomarkers and two PARP inhibitors are approved for metastasic CRPC (mCRPC) pts. Published data are predominantly focused on tissue-based assays, but ...

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关键词

homologous recombination repair,pathogenic variants,metastatic crpc,genes

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