Synthesis Of Beta-Acylamino Furans From Glucosamine

A facile method for the synthesis of a series of novel beta-acylamino furans stating from renewable monosaccharide was achieved. Glucosamine hydrochloride was selectively N-acylated with acyl chlorides in methanol/triethylamine to yield N-acyl-d -glucosamines, which were subsequently converted into beta-acylamino furans through dehydration and cyclization under microwave irradiation.