Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences

Key summary points Aim This narrative review aims to find and summarize recent publications on definitions, epidemiology and clinical consequences of polypharmacy. Findings Numerous definitions of polypharmacy and associated terms were found. The prevalence of polypharmacy greatly varies, and numerous adverse clinical outcomes were associated with polypharmacy. Message The clinically oriented definitions of polypharmacy are more useful and relevant. Regardless of the definition, polypharmacy is highly prevalent in older adults. Approaches to increase the appropriateness of polypharmacy can improve clinical outcomes in older adults.