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Gliclazide charge transfer complexes with some benzoquinone acceptors: Synthesis, structural characterization, thermal analyses, DFT studies, evaluation of anticancer activity and utility for determination of gliclazide in pure and dosage forms

Journal of Molecular Structure(2021)

Cited 14|Views10
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Abstract
•The CT complexes of gliclazide with DDQ and PCA were of 1:1 stoichiometric ratio.•DDQ and PCA were used successfully to determine GLZ in diamicron and diamedizen tablets.•GLZ underwent CT complexation as a n-donor drug.•DFT and TD-DFT calculations were carried out for the formed complexes.•The CT complexes were screened for their anticancer activity against breast cancer cell line.
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Key words
Gliclazide,DDQ,Chloranilic acid,Spectrophotometry,TD-DFT,Anticancer activity
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